Endocrine Abstracts

Levothyroxine suppression therapy, i.e. keeping the TSH value below 0.3 mIU/l with the aim to reduce the total thyroidal tissue or nodule volume, is an arguable and controversial issue not only due to the effect upon nodule volume but also because of the extent of necessary suppression, the effect of incomplete suppression, long-time therapeutic effects and risk of cardiovascular problems and osteoporosis.The incidence of nodular alterations rises with a...

Introduction: Scintigraphy had long been the only modality for thyroid gland imaging. With the development of other imaging techniques (sonography, CT, MRI), the role of scintigraphy has gradually diminished. However, it cannot be completely ignored, as it is the only technique to image not only the morphological structure, but also the functional status of the thyroid gland. In the current clinical practice, thyroid scintigraphy is performed with 99mTc pertechnetat...

MC3-R expressed in the brain are well characterized however the role of MC3-R in the periphery is unclear. Recently, we described immunopositive staining for MC3-R in the testes of wild-type mice and reported that the testicular histology of the MC3-R null mouse was abnormal. The aims of this further work were to confirm that MC3-R is expressed in testes and determine if ACTH1–39 affects testicular steroidogenesis in vitro.RNA and ...

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...

The mechanism by which the thionamide antithyroid drugs produce long-term remission of Graves’ hyperthyroidism is unknown. We wished to explore the hypothesis that methimazole (MMI) could induce a structural change in thyroid peroxidase (TPO), such that its major (immunodominant) epitope(s) was no longer recognised by circulating anti-TPO antibodies.An enzymatically active membrane preparation of a CHO cell-line stably transfected with human TPO was...

Objective: Vitamin D deficiency is common in polish population and seem to play role in pathogenesis of some diseases. We looked for correlation between polymorphisms BsmI, TaqI, ApaI and FokI of vitamin D receptor and vitamin D influence on goiter development.Methods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood s...

Objective: There are many suggestions of predispositions to goiter in women with benign and malignant masthopaty, we looked for BRCA1 mutations in women wit and without goiterMethods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for BRCA1 were taken, ex05 - p.Cys61Gly; ex 11 polymorphisms K1183R, mutations:...

Back groundBoth pregnancy and polycystic ovary syndrome (PCOS) constitute insulin-resistant states, while gestational diabetes (GDM) is associated with adverse pregnancy outcomes. Though screening for GDM is typically performed later in pregnancy, some women demonstrate significant insulin resistance (IR) and develop GDM even in 1st trimester. We have endeavoured to compare surrogate IR indices in 1st trimester pregnant women and in...

Introduction: The aim of this study was to assess the survival rate of patients with disseminated or inoperable neuroendocrine tumors (NETs) after PRRT with the use of 90Y-DOTATATE combined with long acting somatostatin analogue.Materials and methods: 72 patients were treated with PRRT in our Department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up to a total of 7.4 GBq/m2 administra...